FLOW CYTOMETRY, Kappa & Lambda Light Chains

Kappa & Lambda light chains are used to establish clonality in B-cell neoplasia. Increased Kappa light chains & increased Kappa/Lambda ratio is seen in plasma cell disorders that produce excess monoclonal Kappa light chains. Increased Lambda light chains & decreased Kappa/Lambda ratio is seen in plasma cell disorders that produce excess monoclonal Lambda light chains.